OBESITY AND TYPE 2 DIABETES PI 3-KINASE INSULIN SIGNALING PTP1B OREXIGENIC/ANOREXIGENIC NEUROTRANSMITTERS TRB3 DIABETES SPONTANEOUS PHYSICAL ACTIVITY INSULIN MCH FAT-RICH DIET OBESIDADE KINASE ZUCKER RATS REGULATION OBESITY AMPK GLUCOSE TOLERANCE CANCER CHEMOKINES PARTICULATE MATTER LEPTINA SIGNAL TRANSDUCTION INSULIN ACTION INTERMITTENT FASTING PALMITIC ACID CDC2-LIKE KINASE 2 SKELETAL MUSCLE MUSCLE SINALIZAÇÃO UCP-2 ZUCKER ACETIL-COA CARBOXILASE PROTEIN-TYROSINE KINASE/METABOLISM MCTS TNF-ALFA PRO-INFLAMMATORY PROTEINS SOCS-3 GHRELIN TYPE 2 DIABETES INSULIN RESISTANCE METABOLIC PROGRAMMING LEPTIN SIGNALING WALKER-256 TUMOR MONOCARBOXYLATE TRANSPORTERS (MCTS) AIR POLLUTION PROTEIN AMP-K CITRATE ENERGY HOMEOSTASIS ADIPONECTIN TNF-A HYPERPHAGIA AEROBIC TRAINING HYPOXIA ENERGY CONVERSION LEPTIN CERAMIDES ANXIETY NUTRIGENÔMICA GLUCOSE HOMEOSTASIS PRO-INFLAMATORY RESPONSES IKK EPSILON MICROGLIA CLK2 RAT LIVER FOOD INTAKE ENERGY AUTOPHAGY METFORMINA TREINAMENTO AERÓBIO MITOCHONDRIA COLD TOLL LIKE RECEPTOR CELL PROLIFERATION LIPOTOXICITY TECIDO ADIPOSO PIOGLITAZONE ANOREXIA INFLAMMATION IL-1[BETA] MICE HYPERTENSION CHAPERONE-MEDIATED AUTOPHAGY INTERESTERIFIED FAT ANGIOTENSIN II FEEDING BEHAVIOR FEVER INTERLEUKIN 6 FATTY ACIDS HIGH-FAT DIET PHOSPHATASE ENERGY EXPENDITURE MELATONIN TOPIRAMATO