PROTEIN TYROSINE PHOSPHATASE CHEMICAL SYNTHESIS BIOTECHNOLOGICAL PRODUCTION PROTEIN PHOSPHATASE HUMAN LYMPHOCYTES KINETIC SKIN SUBSTITUTE VERO CELLS LOCAL ANESTHESIA CITRONELLOL V79 FIBROBLASTS NANOSTRUCTED LIPID CARRIERS RAT HEPATOCYTES CULTURE DRUG DELIVERY DIBUCAINE ROPIVACAINE LOCAL ANESTHETIC KINETICS CHITOSAN ANTIHYPERTHYROIDISM DRUG AUTOOXIDATION SORBITOL SOLID LIPID NANOPARTICLES BIOTRANSFORMATION PROCESS OKADAIC ACID